Can’t wake them, seizure, or trouble breathing? Call 911 (U.S.)Overdose response

A HARM REDUCTION GUIDE

Know more.
Stay safer.

Straightforward information on drug effects, dose risks, and testing. For yourself, a friend, or anyone who needs it.

Substance library

Look up effects, dose risks, interactions, and warning signs.

PRESCRIPTION STIMULANT

Adderall

Checking pills, delayed effects with XR, and dangerous combinations.

Read guide
EMPATHOGEN / STIMULANT

MDMA Molly · Ecstasy

Delayed effects, overheating, and checking pills or powder.

Read guide
PSYCHEDELIC

LSD Acid

How long effects can last, what a reagent can tell you, and how to help a friend.

Read guide
OPIOID

Opioids

Fentanyl, changes in tolerance, slow breathing, and using naloxone.

Read guide
SEDATIVE

Benzodiazepines Benzo · Xanax

Using without a prescription, checking pills, and recognizing overdose or withdrawal.

Read guide
CANNABIS

Cannabis THC · Weed

Compare THC labels and timing for flower, vapes, concentrates, edibles, oils, and topicals.

Read guide
DISSOCIATIVE

Ketamine K

Weighing powder, why route matters, and which combinations raise overdose risk.

Read guide
PSYCHEDELIC

Psilocybin mushrooms Shrooms

Dry weight, variable potency, and what to do after a possible mushroom mix-up.

Read guide
DEPRESSANT

Alcohol

Count standard drinks and recognize alcohol poisoning and withdrawal.

Read guide
STIMULANT

Cocaine and crack Coke · Crack

Why line size is unreliable, how crack differs, and what to test.

Read guide
STIMULANT

Methamphetamine Crystal meth

Compare routes and timing, weigh crystal, and recognize stimulant overdose.

Read guide
DEPRESSANTS

GHB, GBL and 1,4-BD G

Know which liquid you have, what mL means, and why mixing is dangerous.

Read guide
DISSOCIATIVE

Dextromethorphan DXM

Read mg per tablet or mL and check for other active ingredients.

Read guide
INHALANT / DISSOCIATIVE

Nitrous oxide Whippets · Nangs

Reduce oxygen loss and cold burns, and spot early nerve symptoms.

Read guide
INHALANT

Poppers Alkyl nitrites

Prevent swallowing and burns, and check for dangerous medication interactions.

Read guide
PSYCHEDELIC

2C-B 2CB

See a real dose reference and learn why a small weighing error matters.

Read guide
PSYCHEDELIC

DMT and ayahuasca N,N-DMT

Compare inhaled DMT with ayahuasca and check MAOI interactions.

Read guide
PSYCHEDELIC

Mescaline Peyote · San Pedro

Compare pure mescaline with cactus and learn why effects can build slowly.

Read guide
PSYCHEDELIC

5-MeO-DMT Bufo

A distinct drug from DMT, with higher risks from blackouts, vomiting, and MAOIs.

Read guide
HALLUCINOGEN

Salvia divinorum Salvia

Understand extract labels, sudden disorientation, and fall risk.

Read guide
SYNTHETIC HALLUCINOGENS

NBOMe and NBOH 25I · 25B · 25C

Recognize an LSD look-alike and know what a blotter test can tell you.

Read guide
VARIABLE MIXTURE

Tusi Pink cocaine

The name and pink color give no reliable ingredient list or dose.

Read guide
SYNTHETIC CANNABINOID

Synthetic cannabinoids K2 · Spice

Why cannabis dose guidance can’t transfer to K2, Spice, or sprayed products.

Read guide
STIMULANTS

Synthetic cathinones 3-MMC · Mephedrone

Compare what’s known about 3-MMC with mislabeled powders and other cathinones.

Read guide
SYNTHETIC OPIOIDS

Nitazenes

Know the limits of fentanyl and nitazene strips and how to respond to overdose.

Read guide
NON-OPIOID SEDATIVES

Xylazine and medetomidine Tranq · Mede

Distinguish two sedatives and learn when to get help for wounds or withdrawal.

Read guide
OPIOID-LIKE EFFECTS

Kratom and 7-OH 7-hydroxymitragynine

Tell leaf products from concentrated 7-OH and read milligrams per serving.

Read guide

DOSING BASICS

How to measure a dose

A scale tells you what the sample weighs. Check a verified label or ask a lab to find out how much drug it contains.

Read the units

1 g = 1,000 mg. 1 mg = 1,000 µg. Check the decimal. 0.100 g = 100 mg. 0.010 g = 10 mg.

Weigh crystals, powder, or dried material

Use a milligram scale on a flat surface. Check its minimum reliable weight. Put the empty tray on the scale, press tare to zero it, then add the sample. Wait for the number to settle.

Check pills from an unverified source

A stamp or score line can’t tell you what’s in a pill. Ask a drug-checking service if it can identify the drug and measure its strength.

Know when a scale can’t help

A scale can’t tell you how much LSD is on paper or fentanyl is in a mix. For edibles, read mg of THC per serving and per pack. For liquids with a verified label, check mg per mL and use a marked syringe or cup.

Sources

Measuring and testing · NZ Drug Foundation · BCCSU Drug Checking · Institute for Safe Medication Practices (PDF)

More ways to reduce risk

DRUG CHECKING

What’s in a sample?

A test can find unexpected drugs. It can also miss them. Results apply only to the sample you tested.

TARGETED SCREEN

Fentanyl test strips

Strips check for fentanyl. They can miss it and can’t measure how much is there.

Read strip results
COLOR SCREEN

Reagent kits

Drops change color and give clues about what’s in a sample. They can miss drugs in a mix and can’t measure dose.

Compare test kits
Sources

Methods and limits · BCCSU Drug Checking · DanceSafe

Where to get test kits

Follow your kit’s directions and check the expiry date.

Rapid Response fentanyl strips

For powders and liquids. Results can vary by strip model and batch.

BTNX strips (U.S.)

LSD reagent kit

A color change gives a clue. It can’t confirm LSD or tell you how strong it is.

DanceSafe LSD kit

Cocaine reagent kit

Multiple reagents can screen a sample for cocaine and give clues about some other ingredients. Use a separate fentanyl strip for fentanyl.

DanceSafe cocaine kit

2C-B reagent kit

Compare multiple color reactions. Some other drugs give similar colors, and the kit can’t measure strength.

Test Kit Plus 2C-B kit
Sources

Test performance · Independent fentanyl strip study · DanceSafe reagent guidance

Reading a fentanyl strip

Follow your kit for how much water to add, when to dip the strip, and when to read it. Too little water can cause a false positive.

LA County illustrated guide (PDF)
Positive
Fentanyl may be present. Skip this sample.
Negative
The strip may have missed fentanyl. Other drugs can still be present.
Invalid
No control line? Use a fresh strip and check the directions.

BEFORE USING

What changes the risk?

Strength, timing, your health, and other drugs all affect risk.

Check the form and route

Swallowing and inhaling can hit at different speeds. Check the guide for the form you have.

Avoid taking more while effects build

Swallowed and slow-release drugs can take hours to reach full effect. Don’t take more just because you feel nothing yet.

Watch for combinations

Mixing alcohol, opioids, or benzos can slow breathing. Mixing stimulants can strain your heart. Ask a pharmacist about your medications.

Make it easy to get help

Have a sober person nearby. Tell them what you took. Keep naloxone handy if opioids might be involved.

Sources

Risk reduction · CDC stimulant guide · SAMHSA overdose toolkit

OVERDOSE RESPONSE · U.S.

When to get help

Call immediately if someone can’t be woken, is breathing slowly or irregularly, collapses, has a seizure, or develops chest pain or severe overheating.

Call 911

Outside the U.S., call your local emergency number.

  1. Call for help and follow the dispatcher. Say where you are and what they took, if you know. Follow instructions for CPR or rescue breaths.
  2. Give naloxone if opioids might be involved. If breathing is still abnormal after 2–3 minutes, use a new dose.
  3. Stay with them until help arrives. If they’re unconscious and breathing normally, turn them onto their side. Keep checking breathing.
Sources

CDC overdose response · CDC naloxone guide

Sources and support

Read the original guidance, get exposure advice, or find care near you.

Prism photograph by Artem on Unsplash.